By W. Jelkmann, A. J. Gross (auth.), Professor Dr. med. Wolfgang Jelkmann, Dr. med. Andreas J. Gross (eds.)
The publication includes a sequence of up to date overview articles at the body structure and pathophysiology of the keep an eye on of the creation of pink cells by means of the hormone erythropoietin. additionally, the consequences are said of preliminary scientific trials utilizing recombinant human erythropoietin (rhuEpo) within the therapy of the anemia of renal failure. The introductory bankruptcy in short recollects the historical past of erythropoietin examine. the next part at the chemistry and body structure covers info of the constitution of the hormone, assay equipment, the id of renal and extrarenal websites of the creation of erythropoietin via in situ hybridization and the hypoxic stimulation of its construction. a different bankruptcy is dedicated to the rules of erythropoiesis within the neonatal interval. There follows a bit on pathophysiology, along with respiration, renal and malignant ailments in people. within the ultimate part the pharmacology of rhuEpo is taken into account. the tactic of the cloning and in vitro expression of the erythropoietin gene is defined. 4 chapters summarize scientific observations of the results of rhuEpo within the correction of the anemia of renal failure, together with the increase in hematocrit, blood viscosity and doubtless high blood pressure, and the elevated actual paintings capability of the sufferers. The monograph will turn out precious not just to investigators operating within the uncomplicated fields of body structure, pharmacology and endocrinology, but in addition to practicing physicians, particularly hematologists and nephrologists, who're attracted to erythropoietin for diagnostic or healing reasons.
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Additional info for Erythropoietin
Koury ST, Bondurant MC, Koury MJ (1988) Localization of erythropoietin synthesizing cells in murine kidneys by in situ hybridization. Blood 71:524 8. Lacombe C, Da Silva J-L, Bruneval P, Fournier J-G, Wendling F, Casadevall N, Camilleri J-P, Bariery J, Varet B, Tambourin P (1988) Peritubular cells are the site of erythropoietin synthesis in the murine hypoxic kidney. J Clin Invest 81:620 9. Rich IN, Vogt C, Pentz S (1988) Erythropoietin gene expression in vitro and in vivo detected by in situ hybridization.
Blood 36: 607-616 26. Garcia JF, Ebbe SN, Hollander L, Cutting HO, Miller ME, Cronkite EP (1982) Radioimmunoassay of erythropoietin: circulating levels in normal and polycythemic human beings. J Lab Clin Med 99: 624-635 27. Gidding SS, Stockman JA (1988) Erythropoietin in cyanotic heart disease. Am Heart J 116: 128-132 28. Guidet B, Offenstadt G, Boffa G, Najman A, Baillou C, Hatzfe1d C, Amstutz P (1987) Polycythemia in chronic obstructive pulmonary disease. Chest 92: 867-870 29. Haga P, Cotes PM, Till JA, Minty BD, Shinebourne EA (1987) Serum immunoreactive erythropoietin in children with cyanotic and acyanotic congenital heart disease.
No inflammatory interstitial cells were observed. When compared with the normal mouse kidney, the peri tubular capillary endothelial cells of the anemic mouse kidneys exhibited prominent rough and smooth reticulum, Golgi apparatus, and free polyribosomes (Fig. 5). Discussion These results demonstrate that under hypoxic conditions, the renal cells producing Epo in mice are in a peritubular location. Neither the glomeruli nor the tubules are involved in Epo mRNA synthesis in this animal model. However, given the sensitivity of the in situ hybridization technique, it cannot be ruled out that other renal cells are involved in Epo production under physiologic conditions.