By K. Sandhoff, P. Leinekugel (auth.), J. A. F. Op den Kamp (eds.)
Membrane proteins, lipids and their glycosylated derivatives are mentioned either with admire to their biosynthesis in addition to concerning their mutual interplay and meeting into practical membranes. subject matters hide a wide number of platforms and cells: research on virus membranes in addition to professional- and eukaryotic cells are included.
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Mol Cell BioI 4:2697-2704. Buss JE, Solski PA, Schaeffer JP, MacDonald MJ, Der CJ (1989) Activation of the cellular protooncogene product p21Ras by addition of a myristylation signal. Science 243:1600-1603. Calothy G, Laugier D, Cross FR, Jove R, Hanafusa T, Hanafusa H (1987) The membrane-binding domain and myristylation of p60 v - src are not essential for stimulation of cell proliferation. J Virol 61:1678-1681. Caras IW, Weddel GN, Davitz MA, Nussenzweig V, Martin DW Jr (1987) Signal for attachment of a phospholipid membrane anchor in decay accelerating factor.
Thus, it seems likeley that GPI anchored proteins, being attached to the membrane by a phospholipid moiety, would be relatively more mobile in the bilayer than integral proteins. , 1987). Furthermore, it has been speculated that GPI anchored proteins may be involved in transducing signals across a membrane (Low, 1989). After being activated by an external stimulus, this high lateral mobility may allow GPI anchored proteins to rapidly interact with transmembrane proteins, which would then transduce the signal across the membrane to activate second messenger systems.
1985), where free and bound water molecules are assumed to exchange rapidly 51 between the sites. The observed quadrupole splitting within this model then follows the equation ~2H=nXL/Xw IXSI where XL and Xw are the mole fractions of lipid and water, respectively, X is the quadrupole coupling constant, S is the order parameter, and n is the average number of water molecules bound to each group. By plotting ~2H against XL/X w a straight line is obtained strongly indicating that water molecules added to the La.