Dendritic Cells by Giovanna Lombardi, Yanira Riffo Vasquez

Dendritic Cells by Giovanna Lombardi, Yanira Riffo Vasquez

By Giovanna Lombardi, Yanira Riffo Vasquez

This publication offers within the first half an summary of dendritic telephone (DC) biology and the function of DCs in a few human illnesses. the second one a part of the ebook illustrates a number of the means that DCs might be manipulated for immunotherapy to both result in tolerance in autoimmunity and transplantation or improve the immune responses comparable to in an infection or melanoma.

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1994). The TLR expression of the conventional DC in mice and the human myeloid DC differs widely unlike the TLR expression of mouse and human PDC (Tables 1 and 2) (Jarrossay et al. 2001; Kadowaki et al. 2001). Human myeloid DC express high levels of TLR2 and TLR5, while monocyte-derived DC express high levels of TLR2 and TLR4. In contrast to PDC, human myeloid DC and monocyte-derived DC do not express TLR7 and TLR9. Nevertheless, these non-PDC subsets respond to viral ssRNA via stimulation of TLR8.

2001). The DC subset with intermediate levels of DEC-205 is found in all lymph nodes, lacks CD4 and CD8α expression, and can be distinguished from the other DN DC subset because they express CD11b. This DC subset is believed to be derived from interstitial DC. In contrast to this, the DC subset with high levels of DEC-205 expresses langerin, which is a marker for epidermal Langerhans cells. These DC are only found in skindraining lymph nodes and are therefore thought to be derived from Langerhans cells.

J Biol Chem 279:32035–32045 Lund J, Sato A, Akira S, Medzhitov R, Iwasaki A (2003) Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells. J Exp Med 198:513–520 Lund JM, Alexopoulou L, Sato A, Karow M, Adams NC, Gale NW, Iwasaki A, Flavell RA (2004) Recognition of single-stranded RNA viruses by Toll-like receptor 7. Proc Natl Acad Sci U S A 101: 5598–5603 Mahnke K, Guo M, Lee S, Sepulveda H, Swain SL, Nussenzweig M, Steinman RM (2000) The dendritic cell receptor for endocytosis, DEC-205, can recycle and enhance antigen presentation via major histocompatibility complex class II-positive lysosomal compartments.

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