By Yvan Touitou, Erhard Haus
Everyone has heard of nature's "biological clocks", the phenomenon of periodic task in crops, animals and people. yet what does chronobiology need to do with sleek drugs?
This publication provides in a concise yet accomplished model the fundamental ideas of chronobiology and their software to medical medication.
The chapters are written by way of experts within the box; they summarize the body structure, pathophysiology and pathology of the human time constitution and description the appliance of chronobiologic ideas and strategies for analysis and treatment.
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Extra info for Biologic Rhythms in Clinical and Laboratory Medicine
Touitou tails on observations on transmeridian flights and shift work see the chapters by Reinberg and Smolensky, and by Winget et al. During phase adaptation the usual phase relation between fast- and slow-adapting rhythms will be altered leading to an "internal desynchronization" of rhythms. The usual phase relation between rhythms is thought to be of importance for certain body functions. If a disruption of this relation occurs during a rapid phase shift forced upon the organism by a sudden change in the phase of the environmental synchronizer, a transient functional impairment may result which may become clinically manifest as "jet lag" with performance decrements, sleep disorders, gastrointestinal disorders, etc.
Extensive mapping to establish the usual ranges for rhythm parameters in different frequency ranges and their time relations is presently underway and preliminary information providing some chronobiologic reference values has been published (Haus et al. 1984a, 1988, 1990b; Haus and Halberg 1980; Pocock et al. 1989; Kanabrocki et al. 1987,1990; Scheving et al. 1977; Touitou et al. 1979, 1986, 1989). Much additional work, however, still has to be done, which requires worldwide cooperation between numerous laboratories with standardization of techniques of sampling and measurement, and establishment of a generally accessible computerized data bank.
1983; Hrushesky et al. 1979; Hughes et al. 1976; Lakatua et al. 1979, 1986; Spelsberg et al. 1979; Haus et al. 1988; Sensi et al. 1984; Touitou et al. 1983 a, b, 1984, 1986; Holdaway et al. 1990). Time-Dependent Changes in Sensitivity, Resistance and Responsiveness The periodically changing functional state of the organism and of its subsystems leads to time-dependent differences in the handling of metabolic loads 22 E. Haus and Y. • '3 50 g •E j ~ 30 ~ z 0800 1600 0000 Time (clock hours) 0800 0800 1600 0000 0800 Time (clock hours) Fig.