By Dale J. Benos (Eds.)
Sodium reabsorbing epithelia play a tremendous function in whole-body sodium homeostasis. a few examples of sodium regulating tissues comprise kidney, colon, lung, and sweat ducts. Sodium delivery throughout those membranes is a two-step method: access via an amiloride-sensitive sodium channel and go out through the ouabain-sensitive sodium/potassium ATPase. The sodium access channels are the rate-limiting determinant for delivery and are regulated by way of a number of diversified hormones. The sodium channels additionally play an important function in a couple of affliction states, like high blood pressure, edema, drug-induced hyperkalemia, and cystic fibrosis. Amiloride-Sensitive Sodium Channels: body structure and useful variety offers the 1st in-depth alternate of rules referring to those sodium channels, their rules and involvement in common and pathophysiological events. Key beneficial properties * Summarizes present nation of amiloride-sensitive sodium channel box * Analyzes structure-function of epithelial sodium channels * Discusses immunolocalization of epithelial sodium channels * Examines hormonal rules of sodium channels * Discusses sodium channels in lymphocytes, kidney, and lung * Considers mechanosensitivity of sodium channels * offers rules on sodium channels and affliction
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Extra info for Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity
Acknowledgment The authors were supported by NIH Grant DK 37206 from the National Institute of Diabetes, Digestive, and Kidney Diseases. References Awayda, M. , Ismailov, I. , Berdiev, B. , Fuller, C. , and Benos, D. J. (1996). Protein kinase regulation of a cloned epithelial Na' channel. J. Gen. Physiol. 108, 49-65. Benos, D. , Saccomani, G.. Brenner, B. M.. and Sariban-Sohraby, S . (1986). Purification and characterization of the amiloride-sensitive sodium channel from A6 cultured cells and bovine renal papilla.
Berdiev, B. , Lifton. R. , Fuller, C. , Achard, J. , Benos, D. , and U'arnock, D. G . (1996). Liddle's disease: Abnormal regulation of amiloride-sensitive Na' channels by p-subunit mutation. Am. J. Physiol. 270, C208-C213. Canessa, C. , and Rossier, B. C. (1993). Epithelial sodium channel related to proteins involved in neurodegeneration. Nature (London) 361,467-470. Canessa, C. , and Rossier, B. C. (1994a). Membrane topology of the epithelial sodium channel. Am. J. fhysiol. 267, C1682-Cl690.
BNaCl and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels. Proc. Natl. Acad. Sci. U S A . 94,1459-1464. , and Palmer, L. (1997). Epithelial sodium channels: Function, structure and regulation. Physiol. Rev. 77, 359-396. , Chang, S. , Jaeger, N. , Lifton, R. , and Rossier, B. C. (1997). A mutation causing pseudohypoaldosteronism type I identifies a conserved glycine that is involved in the gating of the epithelial sodium channel.